Question: Are cured Cushing’s patients at higher risk for heart problems?

Answer: Chronic Cushing’s syndrome from any cause is bound to damage the cardiovascular system. How much depends on the severity and duration of the condition, and on the genetic predisposition of the patient. The damage results from atherosclerosis (plaque buildup in coronary arteries) due to increased blood pressure, cholesterol and triglycerides. This increases the risk of ischemic heart disease and myocardial infarction. Fortunately, this damage, or most of it, can be reversed after cure from Cushing’s with appropriate lifestyle and diet changes and, if necessary, institution of appropriate pharmacotherapies. It is recommended that patients who had Cushing’s for several years have a preventative visit with a cardiologist.

By Dr. George Chrousos MD (December, 1998)