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Category Archives: Doctor’s Articles

Affective Alterations in Patients with Cushing’s Syndrome in Remission are Associated with Decreased Brain Derived Neurotrophic Factor and Cortisone Levels

BackgroundAffective alterations, including anxiety, emotional lability and apathy might persist in patients who suffered Cushing’s, even long after correction of cortisol excess. Studies using magnetic resonance imaging showed some alterations in the brain of patients in remission for Cushing’s. These alterations were mainly at those regions (hippocampus and prefrontal cortex) in which cortisol acts toContinue Reading

Inferior Petrosal Sinus Sampling in the Diagnosis of Cushing’s Disease

Inferior Petrosal Sinus Sampling (IPSS) plays a vital role in the diagnosis and treatment of Cushing’s disease. Cushing’s disease/Cushing’s syndrome is one of the most challenging diagnosis’ in all of Endocrinology. Testing to aid in the diagnosis can be extensive, time consuming, and can take months to complete. Initially, hypercortisolemia (overproduction of cortisol in theContinue Reading

Coping Strategies have a Strong Impact on Quality of Life, Depression, and Embitterment in Patients with Cushing’s Disease

A chronic illness such as Cushing’s is likely to change your life in many ways. You may have had symptoms from excessive cortisol levels for quite a long time before Cushing’s was suspected and finally confirmed. Diagnosis is oftentimes followed by surgery and may also involve being on medication or receiving radiotherapy. Your illness isContinue Reading

Permanent Adrenal Insufficiency: Effects on Longevity and Quality of Life

Most patients with Cushing’s disease are successfully treated by transsphenoidal pituitary surgery and most cases of adrenal based Cushing’s syndrome require the removal of only one adrenal gland. In cases such as these, adrenal insufficiency (lack of sufficient hormone production from the adrenal glands) is almost always temporary and patients usually recuperate within one year.However,Continue Reading

Vascular Health in Patients in Remission of Cushing’s Syndrome is Comparable with that in Healthy People when Comorbidities are Treated Adequately

Many patients are asking if they have a higher cardiovascular risk as a result of Cushing’s. This article will focus on this question in a group of patients in long-term remission of Cushing’s syndrome.Continue Reading