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Cushing’s After Bilateral Adrenalectomy

Question: I had my entire pituitary gland removed and both adrenals, but still have a lot of Cushing’s symptoms. Is it possible that I still have Cushing’s, but the tests don’t show it? Answer: If your pituitary gland and adrenal glands have been removed, the likelihood of persistent Cushing’s syndrome is very unlikely. Simple biochemicalContinue ReadingContinue Reading

Difference Between Nelson’s Syndrome and a Pituitary Tumor Recurrence

Question: What is the difference between Nelson’s syndrome and a recurrence of a pituitary tumor? Answer: Nelson’s syndrome is a development of a pituitary tumor following bilateral adrenalectomy in patients with Cushing’s disease. In other words, Nelson syndrome can only occur in patients who have both adrenal glands removed. If the adrenal glands have notContinue Reading

How Does Radiation Therapy Work?

Question: How does radiation therapy work? I thought it immediately killed the tumor, but I have heard that isn’t always true. Answer: Radiation therapy does not usually work immediately in any patient with any type of pituitary tumor. Pituitary tumor cells are fairly slow growing and the aim of radiation is to destroy the cellsContinue Reading

Hypopituitarism After Radiation

Question: Following radiation for a pituitary tumor, is there a risk that the entire pituitary will be unable to function normally? Answer: Many patients maintain normal pituitary function following radiation therapy to the pituitary for a few years; however, within ten years, a significant percentage of patients develop some type of pituitary hormone deficiency andContinue Reading

Macroadenoma Recurrence Rate

Question: What percentage of those with pituitary macroadenomas who have transsphenoidal surgery have a recurrence? Answer: For macroadenomas causing Cushing’s, the recurrence rate is about 10% in 10 years. These are often invasive lesionsContinue Reading


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