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Cyclic Cushing’s syndrome

The term “cyclic Cushing’s syndrome” has been used to describe the presence of spontaneous, intermittent periods of cortisol excess that do not occur as a consequence of glucocorticoid therapy (such as prednisone, hydrocortisone or dexamethasone) or other medical intervention. “Periodic hormonogenesis”, “intermittent hypercortisolism”, “unpredictable hypersecretion of cortisol” and “fluctuating steroid excretion” are additional terms usedContinue Reading

Cyclical Cushing’s Syndrome

This article reviews the features of cyclical hypercortisolism (overproduction of cortisol). Cyclical hypercortisolism can lead to considerable clinical dilemmas which are discussed below. Cyclical Cushing’s syndrome is a pattern seen in which the overproduction of cortisol fluctuates within a set rhythm. Before discussing this more it is important to realize that in other cases of Cushing’s the production of cortisol is not fixed at the same level from day to day.Continue Reading

Subclinical Cushing’s Syndrome

What is Subclinical Cushing’s Syndrome? Cortisol has multiple target organs as illustrated in clinical practice by the spectrum of symptoms associated with chronic cortisol excess as observed in long-standing, overt Cushing’s syndrome. The focus of this article is not on overt Cushing’s, but rather on “subclinical” Cushing’s syndrome (SCS). This could be considered an ambiguity,Continue Reading


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