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Category Archives: Molecular Mechanism of Cushing’s

In the Medical Literature

It is truly an exciting time to be involved in the study of the molecular mechanisms of Cushing’s! From a patient’s perspective, useful treatments for Cushing’s based on new findings will be a long time in coming, however it is highly encouraging to know that many excellent researchers are involved in this research. The Spring,Continue Reading

Genetic Changes Found in Cushing’s Disease, Adrenal Tumors and Adrenal Hyperplasia

Cushing’s patients often ask their physicians what caused their rare disease; they want to know if it has anything to do with their DNA and whether it can be inherited. Changes in the building blocks of genes (i.e., mutations) do indeed play a role in the development of tumors that increase adrenocorticotropic hormone (ACTH) orContinue Reading

Research on the Molecular Mechanism of Cushing’s Disease

Cushing disease is caused by pituitary tumors that produce excessive amounts of the pituitary hormone ACTH, leading to excessive synthesis of glucocorticoids by the adrenal glands. Many symptoms of Cushing disease result from these high levels of glucocorticoids and they include fat accumulation, high blood pressure and predisposition to diabetes and osteoporosis. Normally when bloodContinue Reading


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