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Affective Alterations in Patients with Cushing’s Syndrome in Remission are Associated with Decreased Brain Derived Neurotrophic Factor and Cortisone Levels

Background Affective alterations, including anxiety, emotional lability and apathy might persist in patients who suffered Cushing’s, even long after correction of cortisol excess. Studies using magnetic resonance imaging showed some alterations in the brain of patients in remission for Cushing’s. These alterations were mainly at those regions (hippocampus and prefrontal cortex) in which cortisol actsContinue Reading

Coping Strategies have a Strong Impact on Quality of Life, Depression, and Embitterment in Patients with Cushing’s Disease

A chronic illness such as Cushing’s is likely to change your life in many ways. You may have had symptoms from excessive cortisol levels for quite a long time before Cushing’s was suspected and finally confirmed. Diagnosis is oftentimes followed by surgery and may also involve being on medication or receiving radiotherapy. Your illness isContinue Reading

Vascular Health in Patients in Remission of Cushing’s Syndrome is Comparable with that in Healthy People when Comorbidities are Treated Adequately

Many patients are asking if they have a higher cardiovascular risk as a result of Cushing’s. This article will focus on this question in a group of patients in long-term remission of Cushing’s syndrome.Continue Reading

Cushing’s and Osteoporosis

Editor’s Note: This article uses the term Cushing’s syndrome, which includes all forms of Cushing’s, including Cushing’s Disease. Cushing’s syndrome has multiple effects on bone metabolism. Elevated cortisol levels directly inhibit bone formation and indirectly influence the skeleton via effects on reproductive hormones, growth hormone, muscle and fat tissue, intestinal calcium absorption, and renal calciumContinue Reading

Long-term Effects of Cushing’s Syndrome on Adipose Tissue Distribution

“Doctor, since I was successfully treated for Cushing’s syndrome, I have lost a lot of weight but my abdominal fat will just not go away.” This is a sentence that many endocrinologists frequently hear, and something you, as patients, may also recognize. This article will focus on the long-term effects of pituitary or adrenal Cushing’sContinue Reading