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Cushing’s Syndrome and Bariatric Surgery

Most patients with Cushing’s syndrome not only experience weight gain but also develop health complications, such as diabetes mellitus and hypertension. These complications overlap with those seen in patients who seek surgery for weight loss (bariatric surgery). Expert recommendations from many medical societies, including the American Association of Clinical Endocrinologists, Obesity Society, American Society forContinue Reading

Long-term Effects of Cushing’s Syndrome on Adipose Tissue Distribution

“Doctor, since I was successfully treated for Cushing’s syndrome, I have lost a lot of weight but my abdominal fat will just not go away.” This is a sentence that many endocrinologists frequently hear, and something you, as patients, may also recognize. This article will focus on the long-term effects of pituitary or adrenal Cushing’sContinue Reading

The Role of Cortisol in Food Intake and Food Choice Behavior: Two Studies in Patients with Cushing’s

Any endocrinologist familiar with Cushing’s hears from patients that the weight gain associated with Cushing’s is unstoppable, even with calorie restriction and exercise. Several factors have been shown to be causal, including cortisol’s direct effects on fat mass, function, and distribution. Specifically, exposure to excess cortisol increases total fat, and abdominal fat in particular, whileContinue Reading

Why Can Cortisol Make Us Obese?

Professor Onno C. Meijer, PhD, Einthoven Laboratory, Leiden University Medical Center, Leiden, The Netherlands Cushing’s Syndrome is what happens when we are exposed to (way) too much cortisol, or its synthetic variants. Out of the many unwanted aspects of Cushing’s, fat accumulation is the most visible one, and also one of the biggest risks forContinue Reading


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