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Category Archives: Effects of Cushing’s

Affective Alterations in Patients with Cushing’s Syndrome in Remission are Associated with Decreased Brain Derived Neurotrophic Factor and Cortisone Levels

Background Affective alterations, including anxiety, emotional lability and apathy might persist in patients who suffered Cushing’s, even long after correction of cortisol excess. Studies using magnetic resonance imaging showed some alterations in the brain of patients in remission for Cushing’s. These alterations were mainly at those regions (hippocampus and prefrontal cortex) in which cortisol actsContinue Reading

The Role of Cortisol in Food Intake and Food Choice Behavior: Two Studies in Patients with Cushing’s

Any endocrinologist familiar with Cushing’s hears from patients that the weight gain associated with Cushing’s is unstoppable, even with calorie restriction and exercise. Several factors have been shown to be causal, including cortisol’s direct effects on fat mass, function, and distribution. Specifically, exposure to excess cortisol increases total fat, and abdominal fat in particular, whileContinue Reading

Cushing’s and Osteoporosis

Editor’s Note: This article uses the term Cushing’s syndrome, which includes all forms of Cushing’s, including Cushing’s Disease. Cushing’s syndrome has multiple effects on bone metabolism. Elevated cortisol levels directly inhibit bone formation and indirectly influence the skeleton via effects on reproductive hormones, growth hormone, muscle and fat tissue, intestinal calcium absorption, and renal calciumContinue Reading

Hypercortisolism and Memory Impairment

Introduction Memory issues in Cushing’s patients have been reported in the literature over the years however, the number of studies addressing this issue is limited. With the fairly recent advent of new imaging techniques, investigators can now study both the physical structure of the brain and brain metabolites (biochemical compounds) in greater detail using non-invasiveContinue Reading

Cardiovascular Complications of Cushing’s Syndrome

Cushing’s syndrome is characterized by chronic overproduction of cortisol by the adrenal glands. The most frequent cause of Cushing’s syndrome is a benign pituitary tumor (adenoma) that produces adrenocorticotropic hormone (ACTH), which, in turn, stimulates the adrenal glands. Other causes are tumors elsewhere in the body that produce ACTH and adrenal tumors that produce cortisol.Continue Reading