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Category Archives: Doctor’s Articles

The Cost of Cushing’s Disease

Cushing’s disease (CD) is a costly disease, both in terms of its cost to the patient-physical, emotional, and financial-and its cost to society. The costs to the patient are represented by the increased mortality risk, about three-five fold in untreated disease, and the physical costs associated with its significant comorbidities – hypertension, diabetes, cardiac disease,Continue Reading

“Looking” for a Tumor in Patients with Cushing’s Syndrome

Cushing’s syndrome occurs when the adrenal glands produce too much cortisol for a long time. It is most often caused by excessive production of the adrenocorticotrophin hormone (ACTH), which normally is produced by pituitary gland and controls the production of cortisol by the adrenal glands. Excessive ACTH can be made by a tumor in theContinue Reading

Subtle Cognitive Impairments After Long-Term Remission of Cushing’s Disease

Previous studies showed that patients with active Cushing’s disease have cognitive impairments, especially concerning memory functions. Cognition entails the process of thought and incorporates several concepts like memory, association, attention, perception, and problem solving. Those previous studies in patients with active (thus untreated) Cushing’s disease reported impairments in memory, visual- and spatial information, reasoning, verbalContinue Reading

Increased Prevalence of Psychopathology and Maladaptive Personality Traits After Long-Term Remission of Cushing’s Disease

Previous studies showed that in patients with active Cushing’s disease, psychopathology is often observed with major depression being the most common comorbid disorder, although mania and anxiety disorders have also been reported (1). Following successful treatment of Cushing’s disease, both physical and psychiatric signs and symptoms improve substantially (2;3). Furthermore, maladaptive personality traits were documentedContinue Reading

An Update on Dual Release Glucocorticoid Replacement, Spring, 2011

Since 2008, the CSRF has been tracking the progress of a dual release glucocorticoid (cortisol) replacement medication developed by DuoCort Pharma that more closely mimics the natural secretion of cortisol over 24 hours. The original article appeared in the Spring, 2008 issue of the CSRF newsletter and discussed how the medication worked. A second articleContinue Reading

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