Question: How many Cushing’s patients continue to complain of fatigue, depression, aches and pains many years after their Cushing’s has been cured?

Answer: Cushing’s syndrome is a difficult disease to manage. In the best of circumstances, patients feel back to baseline after curative surgery and subsequent steroid taper. In patients who continue to feel fatigue, depression, aches, and pains following curative surgery, we worry that the patient may have persistent adrenal insufficiency, or other types of hypopituitarism. In the presence of such complaints, we generally recommend repeat hormonal testing, in particular that of the adrenal axis, to see if continued steroid replacement is warranted.

Dr. Laurence Katznelson MD (Winter, 2008)