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Category Archives: Doctor’s Articles

Affective Alterations in Patients with Cushing’s Syndrome in Remission are Associated with Decreased Brain Derived Neurotrophic Factor and Cortisone Levels

Background Affective alterations, including anxiety, emotional lability and apathy might persist in patients who suffered Cushing’s, even long after correction of cortisol excess. Studies using magnetic resonance imaging showed some alterations in the brain of patients in remission for Cushing’s. These alterations were mainly at those regions (hippocampus and prefrontal cortex) in which cortisol actsContinue Reading

Inferior Petrosal Sinus Sampling in the Diagnosis of Cushing’s Disease

Inferior Petrosal Sinus Sampling (IPSS) plays a vital role in the diagnosis and treatment of Cushing’s disease. Cushing’s disease/Cushing’s syndrome is one of the most challenging diagnosis’ in all of Endocrinology. Testing to aid in the diagnosis can be extensive, time consuming, and can take months to complete. Initially, hypercortisolemia (overproduction of cortisol in theContinue Reading

Permanent Adrenal Insufficiency: Effects on Longevity and Quality of Life

Most patients with Cushing’s disease are successfully treated by transsphenoidal pituitary surgery and most cases of adrenal based Cushing’s syndrome require the removal of only one adrenal gland. In cases such as these, adrenal insufficiency (lack of sufficient hormone production from the adrenal glands) is almost always temporary and patients usually recuperate within one year.Continue Reading

Vascular Health in Patients in Remission of Cushing’s Syndrome is Comparable with that in Healthy People when Comorbidities are Treated Adequately

Many patients are asking if they have a higher cardiovascular risk as a result of Cushing’s. This article will focus on this question in a group of patients in long-term remission of Cushing’s syndrome.Continue Reading

Adrenal Insufficiency and Cushing’s

Following successful surgical treatment for Cushing’s, either by removal of a pituitary tumor, one or both adrenal glands or ectopic tumor, most patients are adrenal insufficient (cannot make cortisol) for a period of time. Cortisol is essential to life so patients require replacement with a glucocorticoid, such as hydrocortisone or sometimes prednisone. Most patients recovering from Cushing’s require replacement medication only until their body is able to produce adequate cortisol.Continue Reading