The investigators hypothesize that R-roscovitine will suppress pituitary corticotroph tumor ACTH production and normalize urinary free cortisol levels in patients with Cushing disease. To date, R-roscovitine has been evaluated in several Phase I and II studies and has shown early signs of anti-cancer activity in approximately 240 patients. Location: Pituitary Center, Cedars-Sinai Medical Center, Los Angeles,… Continue Reading
Category Archives: Clinical Trials
Research Study: New Imaging Modalities in the Evaluation of Patients with Ectopic Cushing’s Syndrome
Purpose: Cushing’s syndrome is caused sometimes by ectopic ACTH secretion. Finding the exact location of the tumor making extra ACTH is necessary for successful surgical treatment. In 10% to 20% of patients, Cushing’s Syndrome is caused by ectopic production of the hormone ACTH. Often the ectopic ACTH is produced by a tumor of the lung, thymus,… Continue Reading
Research Study: Study of Adrenalectomy versus Observation for Subclinical Hypercortisolism
OBJECTIVES: To see if removing an adrenal tumor by surgery improves blood pressure, diabetes, obesity, osteoporosis, or cholesterol, and cancer detection.… Continue Reading
Category Archives: Clinical Trials
Treatment of Cushing’s Disease With R-roscovitine – A Phase 2 Study
The investigators hypothesize that R-roscovitine will suppress pituitary corticotroph tumor ACTH production and normalize urinary free cortisol levels in patients with Cushing disease. To date, R-roscovitine has been evaluated in several Phase I and II studies and has shown early signs of anti-cancer activity in approximately 240 patients. Location: Pituitary Center, Cedars-Sinai Medical Center, Los Angeles,… Continue Reading
Research Study: New Imaging Modalities in the Evaluation of Patients with Ectopic Cushing’s Syndrome
Purpose: Cushing’s syndrome is caused sometimes by ectopic ACTH secretion. Finding the exact location of the tumor making extra ACTH is necessary for successful surgical treatment. In 10% to 20% of patients, Cushing’s Syndrome is caused by ectopic production of the hormone ACTH. Often the ectopic ACTH is produced by a tumor of the lung, thymus,… Continue Reading
Research Study: Study of Adrenalectomy versus Observation for Subclinical Hypercortisolism
OBJECTIVES: To see if removing an adrenal tumor by surgery improves blood pressure, diabetes, obesity, osteoporosis, or cholesterol, and cancer detection.… Continue Reading
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