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Clinical Trials

This page includes a review of current studies and resources for patients looking for more information on clinical trials for Cushing’s Disease and Cushing’s Syndrome. It will be updated as new studies come to our attention.

National Institute of Health

The National Institute of Health has ongoing research studies involving Cushing’s. If patients fit into an existing research protocol, evaluation and treatment is free of charge. Interested patients or physicians can call the NIH recruitment line at 800-411-1222.

Patients with demonstrated high cortisol and no visible pituitary or ectopic tumor may be eligible an imaging study being conducted by Dr. Lynette Nieman (email: nieman@mail.nih.gov).

Pediatric patients with demonstrated high cortisol may be eligible for pediatric studies. Contact Meg Keil (email: keilm@cc1.nichd.nih.gov).

Clinical Trials Database

The NIH also maintains a database for NIH studies and those underway at other centers (www.clinicaltrials.gov).

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ATR-101 for the Treatment of Cushing’s Syndrome

“A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ATR-101 for the Treatment of Cushing’s Syndrome” is a study for adults with Cushing’s Syndrome and is sponsored by Millendo Therapeutics, Inc. This study will evaluate the efficacy and safety of ATR-101 which is an oral study medication for the treatment of endogenous Cushing’s syndrome. The studyContinue Reading

Are You Living with Endogenous Cushing’s Syndrome?

Now looking for volunteers to participate in SONICS, a clinical study for an investigational drug (COR-003). The purpose of the study is to test the safety and efficacy of COR-003 in the treatment of endogenous Cushing’s syndrome. This study is open-label, which means both the health providers and the participants in the study are aware of the drug or treatment being given. Information from this study will also help doctors learn more about COR-003 in treating endogenous Cushing’s syndrome.Continue Reading

Research Study: New Imaging Modalities in the Evaluation of Patients with Ectopic Cushing’s Syndrome

Purpose: Cushing’s syndrome is caused sometimes by ectopic ACTH secretion. Finding the exact location of the tumor making extra ACTH is necessary for successful surgical treatment.In 10% to 20% of patients, Cushing’s Syndrome is caused by ectopic production of the hormone ACTH. Often the ectopic ACTH is produced by a tumor of the lung, thymus, orContinue Reading

Research Study: Study of Adrenalectomy versus Observation for Subclinical Hypercortisolism

OBJECTIVES: To see if removing an adrenal tumor by surgery improves blood pressure, diabetes, obesity, osteoporosis, or cholesterol, and cancer detection.Continue Reading

Treatment of Cushing’s Disease With R-roscovitine – A Phase 2 Study

The investigators hypothesize that R-roscovitine will suppress pituitary corticotroph tumor ACTH production and normalize urinary free cortisol levels in patients with Cushing disease. To date, R-roscovitine has been evaluated in several Phase I and II studies and has shown early signs of anti-cancer activity in approximately 240 patients.Location: Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CAPrincipalContinue Reading