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Clinical Trials

This page includes a review of current studies and resources for patients looking for more information on clinical trials for Cushing’s Disease and Cushing’s Syndrome. It will be updated as new studies come to our attention.

National Institute of Health

The National Institute of Health has ongoing research studies involving Cushing’s. If patients fit into an existing research protocol, evaluation and treatment is free of charge. Interested patients or physicians can call the NIH recruitment line at 800-411-1222.

Patients with demonstrated high cortisol and no visible pituitary or ectopic tumor may be eligible an imaging study being conducted by Dr. Lynette Nieman (email: nieman@mail.nih.gov).

Pediatric patients with demonstrated high cortisol may be eligible for pediatric studies. Contact Meg Keil (email: keilm@cc1.nichd.nih.gov).

Clinical Trials Database

The NIH also maintains a database for NIH studies and those underway at other centers (www.clinicaltrials.gov).

LINC 3 Clinical Study: Osilodrostat in Patients with Active Cushing’s Disease

A clinical study conducted by Novartis Pharmaceuticals called LINC 3 will see how well osilodrostat lowers cortisol and improves symptoms of Cushing’s disease. Study information LINC 3 is a clinical study for an investigational drug called osilodrostat Osilodrostat is taken by mouth twice a day Some patients will be selected to receive a sugar pillContinue Reading

Research Study: An Open Label Study to Assess the Safety and Efficacy of COR-003 (2S, 4R-ketoconazole) in the Treatment of Endogenous Cushing’s Syndrome

Objectives: To see if inhibition of the excess cortisol production, as well as the signs, symptoms, and medical conditions associated with CS, can be controlled and normalized using NormoCort (also known as COR-003). Continue Reading

Research Study: Mifepristone in children with refractory Cushing’s disease

Researchers at the National Institutes of Health (NIH) want to learn if Mifepristone improves Cushing’s disease in children as it does in adults. Study information: Participants will follow a pre-treatment evaluation and screening period of up to 8 weeks Eligible participants will receive 12 weeks of Mifepristone (there is no placebo) followed by a 12Continue Reading

Research Study: New Imaging Modalities in the Evaluation of Patients with Ectopic Cushing’s Syndrome

Purpose: Cushing’s syndrome is caused sometimes by ectopic ACTH secretion. Finding the exact location of the tumor making extra ACTH is necessary for successful surgical treatment.In 10% to 20% of patients, Cushing’s Syndrome is caused by ectopic production of the hormone ACTH. Often the ectopic ACTH is produced by a tumor of the lung, thymus, orContinue Reading

Research Study: Study of Adrenalectomy versus Observation for Subclinical Hypercortisolism

OBJECTIVES: To see if removing an adrenal tumor by surgery improves blood pressure, diabetes, obesity, osteoporosis, or cholesterol, and cancer detection.Continue Reading